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Technology and applications for matrix-assisted laser desorption/ionization tissue mass spectrometry (MALDI-TMS)

Occurrences in this domain are beyond the reach of exact prediction because of the variety of factors in operation, not because of any lack of order in nature. (Albert Einstein)

MALDI tissue mass spectrometry uncovers the spatial distribution of molecules in herbal, animal and human tissue. In principle, all types of molecules can be imaged and further analyzed in a label-free way: Tissue is covered with a suitable chemical matrix and scanned with a laser that is connected to a mass spectrometer that measures ion intensities for a wide mass range of molecules at all positions (x,y). Proteins, peptides, lipids, drugs and their metabolites are favorite targets. Whereas MALDI-TMS is generally expected to eventually contribute significantly to drug discovery (pharmacology, biomarker discovery), diagnostics (tissue diagnostics) and medical technology (biocompatibility), available technology and applications are not yet robust enough for routine industrial use.

ABIMAS’ not-for-profit research focuses on improved technology and more robust applications for MALDI tissue mass spectrometry, primarily in the pharmaceutical and diagnostics industry. ABIMAS welcomes collaboration with industrial partners.


Recommended reading:

  • Hardesty WM, Caprioli RM (2008). In situ molecular imaging of proteins in tissues using mass spectrometry. Anal Bioanal Chem. 391(3):899-903. Review.
  • Zaima N, Hayasaka T, Goto-Inoue N, Setou M (2010). Matrix-assisted laser desorption/ionization imaging mass spectrometry. Int J Mol Sci. 11(12):5040-55.
  • Solon EG, Schweitzer A, Stoeckli M, Prideaux B (2010). Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. AAPS J. 12(1):11-26.

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